High potency product. Apply sparingly. Limit initial use to no more than every other night. Gradually increase frequency of use to every night as tolerated. Wait 20 minutes after washing to apply a pea-sized amount to clean, dry skin at bedtime. Avoid simultaneous application of other topical treatments/ moisturizers in order to reduce the risk of dryness or irritation of the skin. Store at room temperature 59-86ºF / 15-30ºC.